Even absent of the BiOWiSH® fertilizer enhancement, excess application of fertilizers will contribute to imbalances in the system that may limit the efficacy of any agronomic input. This type of excessive fertilization can cause many imbalances in the soil, any of which may affect potential yield. This situation would be expected to reduce the efficiency response of BiOWiSH® agronomy products, as well as negatively affect native beneficial soil microorganisms.